Stereospecificity of 6'-C-neplanocin A analogues as inhibitors of S-adenosylhomocysteine hydrolase activity and human immunodeficiency virus replication

Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):479-86. doi: 10.1080/07328319808005192.

Abstract

The R- and S-isomers of 6'-C-neplanocin A analogues, which are all known as inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, were studied for their inhibitory effects on Human Immunodeficiency Virus type 1 (HIV-1) replication and HIV-1 Tat-mediated transactivation. The R-isomers showed much greater activity against AdoHcy hydrolase than the S-isomers. The same differential activity was observed against the HIV-1 replication and the Tat transactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / pharmacology
  • Adenosylhomocysteinase
  • Anti-HIV Agents / chemistry*
  • Antibiotics, Antineoplastic / chemistry*
  • Cell Line
  • Enzyme Inhibitors / pharmacology*
  • Hydrolases / antagonists & inhibitors*
  • Molecular Conformation
  • Molecular Structure
  • Transcriptional Activation / drug effects

Substances

  • Anti-HIV Agents
  • Antibiotics, Antineoplastic
  • Enzyme Inhibitors
  • neplanocin C
  • Hydrolases
  • Adenosylhomocysteinase
  • Adenosine