Through deeper understanding of the physiology of wound healing and physico-chemical principles of scarring, biomedical science facilitates the development of new strategies in treatment and prevention of problem scars. It is important for practicing physicians and surgeons to be better aware of the full range of available techniques to control scar formation, and for any medical intervention to be planned in such a way that potential problems are apprehended and minimized or avoided. This article describes the clinical applications of recent research in scar control in order to provide such guidance.