Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells

E Hanon; G Meyer; A Vanderplasschen; C Dessy-Doizé; E Thiry; P P Pastoret

doi:10.1128/JVI.72.9.7638-7641.1998

Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells

J Virol. 1998 Sep;72(9):7638-41. doi: 10.1128/JVI.72.9.7638-7641.1998.

Authors

E Hanon¹, G Meyer, A Vanderplasschen, C Dessy-Doizé, E Thiry, P P Pastoret

Affiliation

¹ Departments of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liège, B-4000 Liège, Belgium. hanon@stat.fmv.ulg.ac.be

Abstract

Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although penetration of BHV-1 is not required, attachment of BHV-1 viral particles is essential for the induction of apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis*
Cattle
Cell Line
Cells, Cultured
DNA Fragmentation
Gene Deletion
Heparin / pharmacology
Herpesvirus 1, Bovine / metabolism*
Herpesvirus 1, Bovine / physiology
Leukocytes, Mononuclear / cytology
Tumor Cells, Cultured
Viral Proteins / genetics
Viral Proteins / physiology*

Substances

Viral Proteins
bovine herpesvirus type-1 glycoproteins
Heparin