Abstract
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in endochondral bone development and adult skeletal homeostasis. Further clarification of these functions will have far-reaching implications in our general understanding of skeletogenesis and the pathophysiology of human skeletal disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis
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Bone Development / physiology*
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Bone Morphogenetic Proteins / physiology
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Bone Remodeling / physiology
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Cartilage / cytology
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Cell Differentiation / drug effects
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Hedgehog Proteins
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Humans
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Mice
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Osteoblasts / physiology
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Osteoporosis / drug therapy
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Parathyroid Hormone-Related Protein / genetics
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Parathyroid Hormone-Related Protein / physiology*
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Receptor, Parathyroid Hormone, Type 1
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Receptors, Parathyroid Hormone / physiology*
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Trans-Activators / physiology
Substances
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Bone Morphogenetic Proteins
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Hedgehog Proteins
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PTH1R protein, human
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Parathyroid Hormone-Related Protein
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Receptor, Parathyroid Hormone, Type 1
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Receptors, Parathyroid Hormone
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Trans-Activators