Abstract
In an atypical case of stiff-person syndrome (SPS), spinal T2-weighted MRI revealed a hyperintense lesion extending from C2 to C7 that corresponded with the clinical symptoms and signs. CSF showed lymphocytic pleocytosis and oligoclonal bands. Amphiphysin autoantibodies were detected in serum and CSF; however, unlike other reported cases, no malignancy occurred during a 3-year observation period. Methylprednisolone and cyclophosphamide pulse therapy led to a marked reduction of symptoms.
MeSH terms
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Anti-Inflammatory Agents / administration & dosage*
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Autoantibodies / blood
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Female
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Humans
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Immunosuppression Therapy
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Magnetic Resonance Imaging
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Methylprednisolone / administration & dosage*
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Middle Aged
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Nerve Tissue Proteins / immunology*
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Spinal Cord / immunology
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Spinal Cord / physiopathology*
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Stiff-Person Syndrome / diagnosis
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Stiff-Person Syndrome / drug therapy*
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Stiff-Person Syndrome / immunology*
Substances
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Anti-Inflammatory Agents
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Autoantibodies
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Nerve Tissue Proteins
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amphiphysin
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Methylprednisolone