Abstract
The Escherichia coli low molecular mass penicillin-binding proteins are enzymes associated with the periplasmic face of the inner membrane. This mini review discusses the membrane anchoring of these enzymes and their possible participation in a putative membrane bound protein complex involved in the regulation of peptidoglycan biosynthesis. The identification of such a complex may lead to the identification of new sites of action for antibacterial compounds.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins*
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Carrier Proteins / chemistry*
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Carrier Proteins / metabolism*
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Cell Membrane / enzymology
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Escherichia coli / enzymology*
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Hexosyltransferases*
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Molecular Weight
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Muramoylpentapeptide Carboxypeptidase / chemistry*
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Muramoylpentapeptide Carboxypeptidase / metabolism*
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Penicillin-Binding Proteins
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Penicillins / metabolism
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Peptidyl Transferases*
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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Penicillins
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase