Cardiac disease constitutes a common complication among patients with renal failure. This is partly due to the high incidence of shared risk factors, such as hypertension or diabetes mellitus, and some to specific factors inherent in renal disease. It implies a high incidence of cardiac failure and ischemic heart disease (frequently without significant coronary artery obstructions) with important associated morbidity and mortality. Pericardial disease, valvular involvement and arrhythmia are also common among these patients. The management of these complications in patients with endstage renal disease has some particularities, specially in the field of drug therapy.