Structure and dynamics of ribosomal RNA

S A Woodson; N B Leontis

doi:10.1016/s0959-440x(98)80061-4

Structure and dynamics of ribosomal RNA

Curr Opin Struct Biol. 1998 Jun;8(3):294-300. doi: 10.1016/s0959-440x(98)80061-4.

Authors

S A Woodson¹, N B Leontis

Affiliation

¹ Department of Chemistry and Biochemistry, University of Maryland, College Park 20742-2021, USA. sw74@umail.umd.edu

PMID: 9666324
DOI: 10.1016/s0959-440x(98)80061-4

Abstract

Over the past two years, progress in X-ray crystallography, NMR spectroscopy and electron microscopy has begun to reveal the complex structure of the RNA within the ribosome. The structures of ribosomal proteins L11 and S15, among others, show how RNA-protein interactions organize the conformation of the junctions between ribosomal RNA helices. Genetic and biochemical methods have also identified a three base-pair switch within the 16S rRNA that is linked to mRNA decoding.

Publication types

Review

MeSH terms

Base Sequence
Crystallography, X-Ray
Models, Molecular
Molecular Sequence Data
Nucleic Acid Conformation*
Protein Conformation
RNA, Ribosomal / chemistry*
RNA, Ribosomal / genetics
RNA, Ribosomal / metabolism
RNA, Ribosomal, 16S / chemistry
RNA, Ribosomal, 23S / chemistry
Ribosomal Proteins / chemistry*
Ribosomal Proteins / metabolism
Ribosomes / metabolism
Ribosomes / ultrastructure

Substances

RNA, Ribosomal
RNA, Ribosomal, 16S
RNA, Ribosomal, 23S
Ribosomal Proteins
ribosomal protein L11
ribosomal protein S15