An epidemiological survey of clonorchiasis was conducted at Panqiao township of Yangxin County of Hubei Province from June to November, 1993. The positive rate of cercaria in the body of intermediate hosts, Parafossarulus stratulus and Alocinma longicornis was 12.25% and 3.84% respectively. Positive rates of metacercariae in the bodies of Pseudonaphona parva was 48.15%, Ctenopharyngodon idellus 17.24% and Hypophthalmichthys nobilis 18.18%. Positive rate of eggs in the feces of cats was 36.36% and pigs 16.67%. It has been confirmed that there is a natural focus of clonorchiasis sinensis at Yangxin County of Hubei Province. A total population of 6,865 in 20 sites of 10 production brigades of Panqiao township was surveyed for infection with Clonorchis sinensis. The average infection rate in the local residents was 5.80%. Male had a higher infection rate than female. The infected persons were mainly peasants and school girls and boys. Most of the infected persons had light infections (I0) without a serious clinical manifestations.