Cloning and analysis of a transcript derived from two contiguous genes of the cathelicidin family

Biochim Biophys Acta. 1998 Jul 9;1398(3):393-6. doi: 10.1016/s0167-4781(98)00076-1.

Abstract

Bac4 is a bovine cathelicidin gene contiguous to another member of this family named Bac7. Although mutations in the sequence suggested that Bac4 gene might be non-functional, primers based on Bac4 specific sequences allowed amplification of a 900 bp cDNA. The transcript comprises the sequences of exons 1, 2 and 3 of Bac7, and of exons 2, 3 and 4 of Bac4 gene and may result from a weak termination control of the transcription of the upstream Bac7 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antimicrobial Cationic Peptides*
  • Base Sequence
  • Blood Proteins / genetics*
  • Cathelicidins
  • Cattle
  • Cloning, Molecular
  • DNA, Complementary
  • Molecular Sequence Data
  • Sequence Analysis, RNA
  • Sequence Homology, Amino Acid

Substances

  • Antimicrobial Cationic Peptides
  • Blood Proteins
  • Cathelicidins
  • DNA, Complementary
  • cationic antimicrobial protein 57, human