To reduce insecurities concerning the pros and cons of psychopharmacological treatment of mental disorders during pregnancy, recent papers on teratogenic risks of different (groups of) drugs, and on therapeutic strategies of psychiatry disorders were reviewed and the results summarised. Psychotropic medication sometimes increases the risk of congenital malformations. It may cause peripartal toxicity and neurobehavioral changes; on the other hand, these risks have to be weighted against the proven benefits of the drugs. Untreated mental disorders seriously endanger the offspring during pregnancy and after delivery, and hence psychopharmacological treatment may be advisable in spite of the risks involved.