Squamous-cell carcinoma of the nasal septum occurs infrequently and only a few cases have been reported. Because of the small number of cases, comparisons between treatment groups have been inadequate. Five patients with this type of tumor are presented. All of them underwent surgery (4 as primary treatment and 1 for recurrence after radiation therapy). One patient had a local recurrence, 2 had cervical metastases, and 2 (40%) died as a consequence of the tumor. In the squamous cell carcinoma of the nasal septum our study supports surgical resection with wide margins combined with postoperative irradiation as the preferred treatment with prophylactic neck dissection for tumors over 2 cm or extended to adjacent areas.