New pyrrole alkaloids from Solanum sodomaeum

K A El Sayed; M T Hamann; H A Abd El-Rahman; A M Zaghloul

doi:10.1021/np980042p

New pyrrole alkaloids from Solanum sodomaeum

J Nat Prod. 1998 Jun 26;61(6):848-50. doi: 10.1021/np980042p.

Authors

K A El Sayed¹, M T Hamann, H A Abd El-Rahman, A M Zaghloul

Affiliation

¹ The Department of Pharmacognosy and National Center for the Development of Natural Products and Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677, USA. elsayed@olemiss.edu

PMID: 9644084
DOI: 10.1021/np980042p

Abstract

Two new pyrrole alkaloids, solsodomine A and B, were isolated from the fresh berries of Solanum sodomaeum L., collected from the Libyan desert. The structures of these compounds were established by 2D-NMR, including 15N NMR spectroscopy and chemical degradation. Solsodomine A (1) shows activity against Mycobacterium intracellulare. This is the first report of pyrrole alkaloids from the genus Solanum.

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Carbohydrate Sequence
Libya
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Molecular Sequence Data
Mycobacterium / drug effects
Plants, Medicinal / chemistry*
Solanaceous Alkaloids / chemistry*
Solanaceous Alkaloids / isolation & purification
Solanaceous Alkaloids / pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Anti-Bacterial Agents
Solanaceous Alkaloids
solsodomine A
solsodomine B