Mollenines A and B: new dioxomorpholines from the ascostromata of Eupenicillium molle

J Nat Prod. 1998 Jun 26;61(6):804-7. doi: 10.1021/np9704056.

Abstract

Two new dioxomorpholines (1 and 2) have been isolated from the sclerotioid ascostromata of Eupenicillium molle (NRRL 13062). Their structures were determined by analysis of NMR data. Mollenine A (1) exhibited moderate cytotoxicity and antibacterial activity, but neither compound displayed significant antiinsectan activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Ascomycota / chemistry
  • Ascomycota / metabolism*
  • Insecticides / toxicity
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Morpholines / isolation & purification
  • Morpholines / pharmacology
  • Soil Microbiology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Insecticides
  • Morpholines
  • mollenine A
  • mollenine B