Abstract
The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Carrier Proteins / genetics*
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Chromosome Mapping
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Chromosomes, Bacterial
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DNA Transposable Elements
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Drug Resistance, Multiple / genetics*
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Evolution, Molecular
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Membrane Transport Proteins*
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Molecular Sequence Data
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Open Reading Frames
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R Factors*
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Restriction Mapping
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Sequence Deletion
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Staphylococcus aureus / genetics*
Substances
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Bacterial Proteins
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Carrier Proteins
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DNA Transposable Elements
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Membrane Transport Proteins
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QacB protein, Staphylococcus aureus
Associated data
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GENBANK/AF053771
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GENBANK/AF053772