Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes

Infect Immun. 1998 Jul;66(7):3449-53. doi: 10.1128/IAI.66.7.3449-3453.1998.

Abstract

An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M protein and the C5a peptidase, both important virulence factors. The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial*
  • Amino Acid Sequence
  • Bacterial Proteins / genetics
  • Base Sequence
  • Chromosome Mapping
  • DNA Transposable Elements*
  • Endopeptidases / genetics
  • Molecular Sequence Data
  • Open Reading Frames
  • Streptococcus pyogenes / genetics*
  • Streptococcus pyogenes / pathogenicity*
  • Virulence / genetics

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • DNA Transposable Elements
  • SIC protein, Streptococcus
  • Endopeptidases
  • C5a peptidase

Associated data

  • GENBANK/AF064540