Abstract
We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PBT) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue / pathology
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Adipose Tissue / transplantation*
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Animals
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Biocompatible Materials
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Biodegradation, Environmental
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Cicatrix / pathology
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Cicatrix / prevention & control
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Collagen
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Dogs
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Dura Mater / pathology*
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Female
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Fibrosis
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Follow-Up Studies
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Laminectomy / adverse effects*
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Longitudinal Studies
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Lumbar Vertebrae / pathology
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Lumbar Vertebrae / surgery
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Male
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Membranes, Artificial*
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Polyesters
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Polyethylene Glycols
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Prospective Studies
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Random Allocation
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Tissue Adhesions / prevention & control
Substances
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Biocompatible Materials
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Membranes, Artificial
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Polyesters
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polyethylene oxide-polybutylene terephthalate copolymer
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Polyethylene Glycols
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Collagen