Synthesis and analgesic properties of new 5-thioaryl pyrazole derivatives

Boll Chim Farm. 1998 Mar;137(3):82-6.

Abstract

A new series 5-thio aryl pyrazole derivatives were proposed aiming analgesic activity. In this work, 8 new compounds of this class were synthesized using usual synthetic methodology, having as key intermediate the 3-methyl-4-nitro-5-chloropyrazole-1-phenyl derivative and subsequent reaction with several nucleophiles sulfides. Pharmacological evaluation of this series showed analgesic activity in the some extent in especially for 5-(4-bromophenyl)-thio-3-methyl-4-nitro-1-phenylpyrazole which was the most potent in this series, presenting an analgesic action comparable to that show by dipyrone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Non-Narcotic / chemical synthesis*
  • Analgesics, Non-Narcotic / pharmacology
  • Animals
  • Mice
  • Pain Measurement / drug effects
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology

Substances

  • Analgesics, Non-Narcotic
  • Pyrazoles