Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones). Synthesis, structure, antimicrobial activity and genotoxicity

J Inorg Biochem. 1998 Feb 1;69(1-2):101-12. doi: 10.1016/s0162-0134(97)10027-7.

Abstract

Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(2-hydroxybenzoylhydrazone) (H5dfps) and pyrrole-2,5-dicarboxaldehyde bis(2-picolinoylhydrazone) (H3dfpp) were synthesized and characterized by IR, 1H and 119Sn NMR spectroscopy. X-ray analysis of the complex [Sn(H3dfps)(C6H5)2].(CH3)2SO revealed a pentacoordination around tin through a N,N,O terdentate ligand behaviour of the hydrazone. This complex is the most active compound, exhibiting MIC values of 3 and 12 micrograms/ml against Gram positive and Gram negative bacteria, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in the Salmonella-microsome test.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • DNA Damage*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Models, Chemical
  • Models, Molecular
  • Organotin Compounds / chemical synthesis*
  • Organotin Compounds / chemistry
  • Organotin Compounds / pharmacology
  • Spectrophotometry, Infrared
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Organotin Compounds