[Change in prostanoid metabolism in cystic kidney lesion]

Abstract

A wide range of renal prostaglandins in cysts has been studied as compared with their content in the daily urine, activity of plasma renin, level of adrenocorticotropic hormone (ACTH) in the tissues, methionine enkephalin and aldosterone. High activity of renin, met-enkephalin and ACTH was observed in the patients with one cyst. Under renal polycystosis the activity of plasma renin is higher and the amount of ACTH positively decreases. The comparison of prostanoids content in the cystic fluid of a single cyst and polycystic one demonstrates that the polycystic level of all prostanoids in the punctate increase 2-3 times.