Abstract
We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abnormalities, Multiple / genetics
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Abnormalities, Multiple / immunology*
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Adolescent
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Adult
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Child
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Child, Preschool
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Chromosome Deletion*
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Chromosomes, Human, Pair 22*
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Cross-Sectional Studies
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DiGeorge Syndrome / genetics
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DiGeorge Syndrome / immunology*
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Female
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Genetic Testing
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Humans
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IgA Deficiency / epidemiology*
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Immunoglobulin A / blood
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In Situ Hybridization, Fluorescence
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Male
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Odds Ratio
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Prevalence