Abstract
The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cryptococcus neoformans / growth & development
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Cryptococcus neoformans / immunology*
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Culture Media
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*
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Humans
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Interferon-alpha / pharmacology*
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Microglia / immunology*
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Microglia / microbiology
Substances
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Culture Media
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Interferon-alpha
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Granulocyte-Macrophage Colony-Stimulating Factor