Abstract
In continuation of the development of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, a series of N-aminoalkyl derivatives of (s)-(+)-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H, 11aH)-dione was prepared. Evaluation of these compounds in revealed a very low affinity for 5-HT1A receptor.
MeSH terms
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Animals
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Anti-Anxiety Agents / chemical synthesis*
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Anti-Anxiety Agents / metabolism
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / metabolism
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Brain Stem / metabolism
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Magnetic Resonance Spectroscopy
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Rats
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Receptors, GABA-A / metabolism
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Spectrophotometry, Infrared
Substances
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Anti-Anxiety Agents
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Receptors, GABA-A
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Benzodiazepines