Abstract
We examined vascular amyloid-beta deposition and other abnormalities in the posterior cerebral artery of consecutive cases of Alzheimer's disease (AD) compared to controls. Smooth muscle atrophy was a consistent feature in the cases of AD examined (p<0.01) and was surprisingly independent of adjacent amyloid-beta deposition. These findings suggest that vascular abnormalities are a consistent feature in AD and may be an important contributor to the pathogenesis and complications of AD.
Copyright 1998 Elsevier Science B.V.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Alzheimer Disease / etiology
-
Alzheimer Disease / metabolism
-
Alzheimer Disease / pathology*
-
Analysis of Variance
-
Case-Control Studies
-
Cerebral Arteries / metabolism
-
Cerebral Arteries / pathology*
-
Cerebrovascular Disorders / complications
-
Cerebrovascular Disorders / metabolism
-
Cerebrovascular Disorders / pathology*
-
Humans
-
Immunohistochemistry
-
Middle Aged
-
Muscular Atrophy / complications
-
Muscular Atrophy / metabolism
-
Muscular Atrophy / pathology*
-
Occipital Lobe / blood supply*