A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus

C Shirai; M Sugai; H Komatsuzawa; K Ohta; M Yamakido; H Suginaka

doi:10.1128/AAC.42.5.1278

A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus

Antimicrob Agents Chemother. 1998 May;42(5):1278-80. doi: 10.1128/AAC.42.5.1278.

Authors

C Shirai¹, M Sugai, H Komatsuzawa, K Ohta, M Yamakido, H Suginaka

Affiliation

¹ Department of Internal Medicine II, Hiroshima University School of Medicine, Japan.

Abstract

Cibacron blue F3GA (CB) was found to reduce the MIC of oxacillin for methicillin-resistant Staphylococcus aureus (MRSA). This effect was not observed with methicillin-susceptible S. aureus. CB alters the resistance level of MRSA through a factor(s) other than mecA-related products, major autolysins, or femAB products. The exact target(s) of CB in causing the effect is unknown.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Interactions
Drug Resistance, Multiple
Methicillin Resistance / physiology
Microbial Sensitivity Tests
Oxacillin / pharmacology
Penicillins / pharmacology
Protein Synthesis Inhibitors / pharmacology*
Staphylococcus aureus / drug effects*
Triazines / pharmacology*

Substances

Penicillins
Protein Synthesis Inhibitors
Triazines
Cibacron Blue F 3GA
Oxacillin