A case of 'pure' dynamic mechano-allodynia due to a lesion of the spinal cord: pathophysiological considerations

Pain. 1998 Apr;75(2-3):399-404. doi: 10.1016/s0304-3959(98)00007-4.

Abstract

We report the unusual observation of a patient who presented with the single symptom of a very intense, brush-induced allodynia (dynamic mechanical allodynia) which was strictly confined to the left C2 and C3 dermatomes. All investigations, including a cervical spinal MRI, were initially normal. The clinical picture remained stable for several months until the appearance of spontaneous pain and sensory deficits suggestive of a spinal lesion. A second MRI revealed an intraspinal lesion involving the C2-C5 segments. In accordance with other clinical and animal studies, such an observation of a 'pure' dynamic mechano-allodynia suggests that specific mechanisms underlie each component of neuropathic pain. Possible pathophysiological mechanisms are discussed in the light of recent experimental results obtained in animals.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Analgesics / therapeutic use
  • Fatal Outcome
  • Female
  • Humans
  • Hyperesthesia / drug therapy
  • Hyperesthesia / etiology*
  • Hyperesthesia / physiopathology
  • Magnetic Resonance Imaging
  • Neck
  • Physical Stimulation
  • Spinal Cord Diseases / complications*
  • Spinal Cord Diseases / diagnosis

Substances

  • Analgesics