Differences in plasma concentrations of the D- and L-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder

Psychiatry Res. 1998 Mar 20;78(1-2):115-8. doi: 10.1016/s0165-1781(97)00138-8.

Abstract

Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D- and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D- and L-threo MPH enantiomers.

MeSH terms

  • Analysis of Variance
  • Attention / drug effects
  • Attention / physiology
  • Attention Deficit Disorder with Hyperactivity / blood*
  • Attention Deficit Disorder with Hyperactivity / classification
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Attention Deficit Disorder with Hyperactivity / physiopathology
  • Central Nervous System Stimulants / blood*
  • Central Nervous System Stimulants / chemistry
  • Central Nervous System Stimulants / pharmacokinetics
  • Child
  • Drug Resistance
  • Event-Related Potentials, P300 / drug effects
  • Event-Related Potentials, P300 / physiology
  • Female
  • Humans
  • Isomerism
  • Male
  • Methylphenidate / blood*
  • Methylphenidate / chemistry
  • Methylphenidate / pharmacokinetics
  • Volition / drug effects
  • Volition / physiology

Substances

  • Central Nervous System Stimulants
  • Methylphenidate