Abstract
Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D- and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D- and L-threo MPH enantiomers.
MeSH terms
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Analysis of Variance
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Attention / drug effects
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Attention / physiology
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Attention Deficit Disorder with Hyperactivity / blood*
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Attention Deficit Disorder with Hyperactivity / classification
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Attention Deficit Disorder with Hyperactivity / drug therapy
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Attention Deficit Disorder with Hyperactivity / physiopathology
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Central Nervous System Stimulants / blood*
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Central Nervous System Stimulants / chemistry
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Central Nervous System Stimulants / pharmacokinetics
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Child
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Drug Resistance
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Event-Related Potentials, P300 / drug effects
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Event-Related Potentials, P300 / physiology
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Female
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Humans
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Isomerism
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Male
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Methylphenidate / blood*
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Methylphenidate / chemistry
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Methylphenidate / pharmacokinetics
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Volition / drug effects
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Volition / physiology
Substances
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Central Nervous System Stimulants
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Methylphenidate