The effect of trimeric 2',5'-oligoadenylic acid and its epoxy-derivative on human immunodeficiency virus (HIV-1) reproduction and retroviruses reverse transcriptase activity

Tkachuk ZYu; S L Rybalko; L I Semernikova; V V Tkachuk; M P Zavelevich; L V Tkachuk; T Eremenko; I A Mikhailopulo; G K Matsuka

The effect of trimeric 2',5'-oligoadenylic acid and its epoxy-derivative on human immunodeficiency virus (HIV-1) reproduction and retroviruses reverse transcriptase activity

New Microbiol. 1998 Apr;21(2):197-201.

Authors

Tkachuk ZYu¹, S L Rybalko, L I Semernikova, V V Tkachuk, M P Zavelevich, L V Tkachuk, T Eremenko, I A Mikhailopulo, G K Matsuka

Affiliation

¹ Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kiev.

PMID: 9579344

Abstract

The effect of trimeric 2',5'-oligoadenylic acid (2',5' A3) and its epoxy-derivative (2',5'-A2 (RAA) on human immunodeficiency virus (HIV-1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under study were used. The interferonogenic effect of both substances was discovered. 2',5'-A2 (RAA) inhibited the activity of retrovirus reverse transcriptase (a C-type).

MeSH terms

Adenine Nucleotides / pharmacology*
Antiviral Agents / pharmacology*
Enzyme Repression
HIV-1 / drug effects*
HIV-1 / enzymology
HIV-1 / physiology
Humans
Oligoribonucleotides / pharmacology*
RNA-Directed DNA Polymerase / drug effects*
Tumor Cells, Cultured
Virus Replication / drug effects

Substances

Adenine Nucleotides
Antiviral Agents
Oligoribonucleotides
2',5'-oligoadenylate
RNA-Directed DNA Polymerase