In this paper the authors present a study of pancreatic fistula after cephalic duodenopancreatectomy concerning the incidence, importance and the therapeutic features in a number of 37 patients operated between 1.Jan.1990-1.Jan. 1997 at the 1st Department of Surgery of Clinical County Hospital of Târgu-Mureş. A number of 8 patients (22%) had pancreatic fistula; a half of them were treated by surgical reintervention, and the second half by conservative procedures.