The zidovudine (ZDV) was the first drug approved to treat the VIH infection. The ZDV prescriptions have been changing throughout the years. Actually it's known that its efficacy is limited over time, and same substances have been discovered which inhibtes more strongly the VIH replication. However the ZDV appears in majority the combined therapy regimens as a first line drug. Even in same special situations there is no existence of another antiretroviral drugs which have showed utility. In this essay it s revised the mainly studies which have provided new knowledge about the ZDV treatment and it s also considered the possibilities of this drug in the more new therapies against the VIH.