Abstract
The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol intake, whereas a 10 mg/kg dose of SR-141716 reduced to a similar extent both ethanol and food intake. These results suggest that the cannabinoid CB1 receptor is involved in the mediation of the ethanol-reinforcing effects in sP rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Drinking / drug therapy*
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Alcohol Drinking / genetics
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Alcohol Drinking / psychology
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Animals
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Cannabinoids / antagonists & inhibitors*
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Central Nervous System Depressants / blood
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Drinking / drug effects
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Eating / drug effects
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Ethanol / blood
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Male
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Piperidines / therapeutic use*
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Pyrazoles / therapeutic use*
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Rats
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Rats, Inbred Strains
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Rats, Wistar
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Receptors, Cannabinoid
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Receptors, Drug / antagonists & inhibitors
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Rimonabant
Substances
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Cannabinoids
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Central Nervous System Depressants
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Piperidines
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Pyrazoles
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Receptors, Cannabinoid
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Receptors, Drug
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Ethanol
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Rimonabant