Abstract
We investigated cytokine levels (interleukin [IL]-1beta, IL-1ra, IL-2, IL-6, tumor necrosis factor [TNF]-alpha, TNF-beta) in plasma and secreted by mitogen-stimulated blood monocytes and lymphocytes; T-cell subsets; and natural killer cell activity in patients with narcolepsy and in human leukocyte antigen (HLA)-DR2 matched controls. The only significant finding was higher IL-6 secretion by monocytes of patients than by those of the HLA-DR2-positive controls. In conclusion, we found no major abnormalities of T-cell function in patients with narcolepsy, but slight alterations of monocyte function deserving further investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Female
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HLA-DR2 Antigen / analysis*
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Histocompatibility Testing
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Humans
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / metabolism
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Interleukin-2 / metabolism
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Interleukin-6 / metabolism
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Lymphotoxin-alpha / metabolism
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Male
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Middle Aged
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Narcolepsy / immunology*
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Sialoglycoproteins / metabolism
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Sleep, REM / immunology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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Tumor Necrosis Factor-alpha / metabolism
Substances
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HLA-DR2 Antigen
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Interleukin-2
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Interleukin-6
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Lymphotoxin-alpha
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Sialoglycoproteins
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Tumor Necrosis Factor-alpha