In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls

Neurology. 1998 Apr;50(4):1149-52. doi: 10.1212/wnl.50.4.1149.

Abstract

We investigated cytokine levels (interleukin [IL]-1beta, IL-1ra, IL-2, IL-6, tumor necrosis factor [TNF]-alpha, TNF-beta) in plasma and secreted by mitogen-stimulated blood monocytes and lymphocytes; T-cell subsets; and natural killer cell activity in patients with narcolepsy and in human leukocyte antigen (HLA)-DR2 matched controls. The only significant finding was higher IL-6 secretion by monocytes of patients than by those of the HLA-DR2-positive controls. In conclusion, we found no major abnormalities of T-cell function in patients with narcolepsy, but slight alterations of monocyte function deserving further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • HLA-DR2 Antigen / analysis*
  • Histocompatibility Testing
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / metabolism
  • Interleukin-2 / metabolism
  • Interleukin-6 / metabolism
  • Lymphotoxin-alpha / metabolism
  • Male
  • Middle Aged
  • Narcolepsy / immunology*
  • Sialoglycoproteins / metabolism
  • Sleep, REM / immunology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • HLA-DR2 Antigen
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Interleukin-2
  • Interleukin-6
  • Lymphotoxin-alpha
  • Sialoglycoproteins
  • Tumor Necrosis Factor-alpha