Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology

J G Richards; J Saura; J M Luque; A M Cesura; J Gottowik; P Malherbe; E Borroni; J Gray

doi:10.1007/978-3-7091-6499-0_17

Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology

J Neural Transm Suppl. 1998:52:173-87. doi: 10.1007/978-3-7091-6499-0_17.

Authors

J G Richards¹, J Saura, J M Luque, A M Cesura, J Gottowik, P Malherbe, E Borroni, J Gray

Affiliation

¹ Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

PMID: 9564618
DOI: 10.1007/978-3-7091-6499-0_17

Abstract

The present report reviews recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.

Publication types

Review

MeSH terms

Alzheimer Disease / enzymology
Animals
Brain / enzymology
Brain / physiology*
Brain / physiopathology
Brain Mapping*
Free Radicals / metabolism
Humans
Isoenzymes / metabolism
Mice
Mice, Transgenic
Monoamine Oxidase / genetics
Monoamine Oxidase / metabolism*
Oxidative Stress
Parkinson Disease / enzymology
Rats

Substances

Free Radicals
Isoenzymes
Monoamine Oxidase