An uncoupling of the processes of oxidation and phosphorylation in glycolysis

E V Schmalhausen; V I Muronetz

doi:10.1023/a:1027356106330

An uncoupling of the processes of oxidation and phosphorylation in glycolysis

Biosci Rep. 1997 Dec;17(6):521-7. doi: 10.1023/a:1027356106330.

Authors

E V Schmalhausen¹, V I Muronetz

Affiliation

¹ A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.

PMID: 9561296
DOI: 10.1023/a:1027356106330

Abstract

Data on alterations of the properties of glyceraldehyde-3-phosphate dehydrogenase upon oxidation of its functional groups are reviewed; a mechanism of uncoupling of oxidation and phosphorylation in glycolysis is considered. Possible ways of regulating uncoupling, and the physiological importance of this process, are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism*
Glycolysis*
Hydrogen Peroxide / pharmacology
Mitochondria / metabolism
Oxidation-Reduction
Oxidative Phosphorylation*
Phosphorylation
Sulfhydryl Compounds / metabolism

Substances

Sulfhydryl Compounds
Hydrogen Peroxide
Glyceraldehyde-3-Phosphate Dehydrogenases