Abstract
221 clinically significant enterococcal strains (191: E. faecalis, 27: E. faecium, 3 others) were isolated from the urine of patients hospitalised with UTI over an 18-month period (1995-1996). The susceptibility of the isolates to 8 antimicrobial agents was determined by agar dilution method (NCCLS). All enterococci were sensitive to vancomycin and most of them (over 92%) to penicillin and ampicillin. Only 3.14% of E. faecalis and 3.70% of E. faecium were resistant to ciprofloxacin. A relatively high incidence of resistance of enterococci to aminoglycosides was observed: 46.07% and 51.85% to streptomycin, 42.41% and 44.44% to gentamicin, 70.68% and 77.78% to amikacin for E. faecalis and E. faecium, respectively. Among the resistant to penicillin and amino glycosides enterococci of the two species was found a great percent "high level" resistance. There were no beta-lactamase producers among our strains. The established multiresistance accompanied by "high level" resistance requires careful consideration of antimicrobial therapy of enterococcal UTI.
MeSH terms
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Adult
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Amikacin / pharmacology
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Ampicillin / pharmacology
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology
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Bacteriuria / microbiology
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Child
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Ciprofloxacin / pharmacology
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Drug Resistance, Microbial
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Enterococcus / classification*
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Enterococcus / drug effects
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Enterococcus / enzymology
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Enterococcus / isolation & purification
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / enzymology
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Enterococcus faecalis / isolation & purification
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Enterococcus faecium / drug effects
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Enterococcus faecium / enzymology
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Enterococcus faecium / isolation & purification
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Gentamicins / pharmacology
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Gram-Positive Bacterial Infections / drug therapy
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Gram-Positive Bacterial Infections / microbiology*
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Humans
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Penicillin Resistance
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Penicillins / pharmacology
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Streptomycin / pharmacology
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Urinary Tract Infections / drug therapy
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Urinary Tract Infections / microbiology*
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Vancomycin / pharmacology
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beta-Lactamases / biosynthesis
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Gentamicins
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Penicillins
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Ciprofloxacin
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Vancomycin
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Ampicillin
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Amikacin
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beta-Lactamases
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Streptomycin