Abstract
Embryotoxic and teratogenic properties of Lophenal, Phenalon, Pharanox and Pharanoxi selenate were investigated experimentally. All examined antitumour agents showed embryotoxic effects. Lophenal, Phenalon and Pharanox had teratogenic effects. By modifying the structure of Pharanox with selenium a reduction in teratogenic effect was achieved.
MeSH terms
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Abnormalities, Multiple / chemically induced*
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Acetates / administration & dosage
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Acetates / adverse effects*
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Acetates / chemistry
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects*
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Female
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Fetus / drug effects*
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Fetus / pathology
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Organoselenium Compounds / administration & dosage
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Organoselenium Compounds / adverse effects*
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Phenylacetates / administration & dosage
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Phenylacetates / adverse effects*
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Pregnancy
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Rats
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Rats, Wistar
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Teratogens / chemistry
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Teratogens / toxicity*
Substances
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Acetates
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Antineoplastic Agents
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Organoselenium Compounds
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Phenylacetates
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Teratogens
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lophenal
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pharanox
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pharanoxi selenate
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phenalon