Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children

Eur Respir J. 1998 Feb;11(2):350-4. doi: 10.1183/09031936.98.11020350.

Abstract

In vitro studies with the Diskus inhaler at low and high flow rates show consistent doses of drug as fine particles <4.7 microm. The present study was designed to ascertain whether this in vitro flow independency translates into flow-independent clinical effect when the device is used by patients at low (30 L x min[-1]) and high (90 L x min[-1]) flow rates. A pilot study in 129 children aged 3-10 yrs demonstrated that 99% of children of 3 yrs and above can generate a flow > or = 30 L x min(-1) through the device, while 26% performed > or = 90 L x min(-1). Eighteen children aged 8-15 yrs with exercise induced asthma inhaled placebo or salmeterol 50 microg at either 30 L x min(-1) or 90 L x min(-1). Exercise challenges were carried out 1 h and 12 h after dosing. The maximum percentage fall in forced expiratory volume in one second (FEVI) after exercise 12 h after treatment was significantly less after salmeterol at either flow rates as compared to placebo. There was no significant difference in the protection from salmeterol on the day of low-flow inhalation versus the day of high-flow inhalation. Consistent in vitro fine particle dosing from the Diskus inhaler translates into a consistent clinical effect at low and high flow rates in children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Albuterol / administration & dosage
  • Albuterol / analogs & derivatives*
  • Albuterol / therapeutic use
  • Asthma, Exercise-Induced / drug therapy*
  • Asthma, Exercise-Induced / physiopathology*
  • Bronchoconstriction / drug effects
  • Bronchoconstriction / physiology
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / therapeutic use
  • Child
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise
  • Female
  • Forced Expiratory Volume / physiology
  • Humans
  • Male
  • Nebulizers and Vaporizers*
  • Powders
  • Pulmonary Ventilation / physiology*
  • Salmeterol Xinafoate

Substances

  • Bronchodilator Agents
  • Powders
  • Salmeterol Xinafoate
  • Albuterol