Abstract
Although drug eruptions resembling graft-versus-host disease are rare, GvH-like reactions to the sulfhydryl group of drugs (penicillamine, captopril, gold sodium), phenobarbital and hepatitis vaccine have been described. Clinical reports concerning acute GvH-like drug rash are very uncommon and restricted to acetylsalicylic acid and spironolactone. We report on a patient who developed an acute GvH-like drug reaction caused by allopurinol. To our knowledge this variant of cytotoxic drug eruption has not yet been reported in literature.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Acute Disease
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Adult
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Allopurinol / administration & dosage
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Allopurinol / adverse effects*
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects*
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Biopsy
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Drug Eruptions / diagnosis*
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Drug Eruptions / pathology
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Graft vs Host Disease / chemically induced*
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Graft vs Host Disease / diagnosis
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Graft vs Host Disease / pathology
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Humans
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Male
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Neoplasm Staging
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Skin / pathology
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Testicular Neoplasms / drug therapy
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Testicular Neoplasms / pathology
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Testicular Neoplasms / surgery
Substances
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Antimetabolites, Antineoplastic
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Allopurinol