Although the pathologic features of arterial disease in diabetes do not differ from those of simple atheromatous lesions, the plurisegmental involvement, the predominant subpopliteal location of lesions and the association with impaired cardiac and renal function in these patients imply peculiar problems in the selection of an adequate therapy. At present, in interventional radiology a number of procedures are available for intravascular therapy (angioplasty, stent, locoregional fibrinolisis, mechanical atherectomy), particularly suitable for diabetics who are affected by multisystem impairment. These procedures are not in opposition to the conventional ones (surgical and medical) but rather integrate them, allowing to extend the indications and improve the results in the treatment of the vasculogenic diabetic foot. Based on the personal experience the potential of intravascular procedures in this disease, is analyzed.