Abstract
Three new naphthalenes, designated as syriacusins A-C, were isolated from the root bark of Hibiscus syriacus. These compounds were identified as 2,7-dihydroxy-6-methyl-8-methoxy-1-naphthalenecarbaldehyde, 2-hydroxy-6-hydroxymethyl-7,8-dimethoxy-1-naphthalenecarbaldehyde, 1-carboxy-2,8-dihydroxy-6-methyl-7-methoxynaphthalenecarbolactone (1-->8), respectively, on the basis of various spectral studies. The compounds inhibited lipid peroxidation with IC50s of 0.54, 5.90 and 1.02 micrograms ml-1, respectively. The first compound also showed cytotoxicity against some human cancer cell lines with an ED50 of 1.5-2.4 micrograms ml-1.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antioxidants / chemistry
-
Antioxidants / isolation & purification*
-
Antioxidants / pharmacology*
-
Humans
-
Lipid Peroxidation / drug effects
-
Liver / drug effects
-
Liver / metabolism
-
Naphthalenes / chemistry
-
Naphthalenes / isolation & purification*
-
Naphthalenes / pharmacology*
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification*
-
Plant Extracts / pharmacology*
-
Plant Roots / chemistry
-
Plants, Medicinal / chemistry*
-
Rats
-
Spectrometry, Mass, Fast Atom Bombardment
Substances
-
Antioxidants
-
Naphthalenes
-
Plant Extracts