Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis

K Barlos; D Gatos; S Koutsogianni

doi:10.1111/j.1399-3011.1998.tb01216.x

Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis

J Pept Res. 1998 Mar;51(3):194-200. doi: 10.1111/j.1399-3011.1998.tb01216.x.

Authors

K Barlos¹, D Gatos, S Koutsogianni

Affiliation

¹ Department of Chemistry, University of Patras, Greece.

PMID: 9531422
DOI: 10.1111/j.1399-3011.1998.tb01216.x

Abstract

Model peptides containing the nucleophilic amino acids Trp and Met have been synthesized with the application of Fmoc/Trt- and Fmoc/tBu-amino acids, for comparison. The deprotection of the peptides synthesized using Fmoc/Trt-amino acids in all cases leads to crude peptides of higher purity than that of the same peptides synthesized using Fmoc/tBu-amino acids.

Publication types

Comparative Study

MeSH terms

Amino Acids / chemistry*
Chromatography, High Pressure Liquid
Fluorenes / chemistry*
Peptides / chemistry*

Substances

Amino Acids
Fluorenes
N(alpha)-fluorenylmethyloxycarbonylamino acids
Peptides