Abstract
Marked lowering of plasma total and low-density lipoprotein cholesterol levels that occur during treatment of dyslipidemia with pharmacologic doses of nicotinic acid result from hepatotoxicity. Therefore, a marked reduction in low-density lipoprotein may suggest generalized liver toxicity and drug treatment should be discontinued.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Acyltransferases / metabolism*
-
Chemical and Drug Induced Liver Injury*
-
Cholesterol, LDL / blood*
-
Humans
-
Liver / physiopathology*
-
Liver Diseases / blood*
-
Liver Diseases / physiopathology
-
Liver Function Tests
-
Male
-
Middle Aged
-
Niacin / adverse effects*
-
Phosphatidylcholines / metabolism*
Substances
-
Cholesterol, LDL
-
Phosphatidylcholines
-
Niacin
-
Acyltransferases
-
cholesteryl ester synthetase