Effects of crystalline nicotinic acid-induced hepatic dysfunction on serum low-density lipoprotein cholesterol and lecithin cholesteryl acyl transferase

Am J Cardiol. 1998 Mar 15;81(6):805-7. doi: 10.1016/s0002-9149(97)01016-3.

Abstract

Marked lowering of plasma total and low-density lipoprotein cholesterol levels that occur during treatment of dyslipidemia with pharmacologic doses of nicotinic acid result from hepatotoxicity. Therefore, a marked reduction in low-density lipoprotein may suggest generalized liver toxicity and drug treatment should be discontinued.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyltransferases / metabolism*
  • Chemical and Drug Induced Liver Injury*
  • Cholesterol, LDL / blood*
  • Humans
  • Liver / physiopathology*
  • Liver Diseases / blood*
  • Liver Diseases / physiopathology
  • Liver Function Tests
  • Male
  • Middle Aged
  • Niacin / adverse effects*
  • Phosphatidylcholines / metabolism*

Substances

  • Cholesterol, LDL
  • Phosphatidylcholines
  • Niacin
  • Acyltransferases
  • cholesteryl ester synthetase