Use of trans-Sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection

M S Leguizamón; G Russomando; A Rojas de Arias; M Samudio; M Cabral; S M González-Cappa; A C Frasch; O Campetella

doi:10.1128/CDLI.5.2.254-255.1998

Use of trans-Sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection

Clin Diagn Lab Immunol. 1998 Mar;5(2):254-5. doi: 10.1128/CDLI.5.2.254-255.1998.

Authors

M S Leguizamón¹, G Russomando, A Rojas de Arias, M Samudio, M Cabral, S M González-Cappa, A C Frasch, O Campetella

Affiliation

¹ Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Paraguay.

Abstract

trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chagas Disease / blood*
Humans
Neuraminidase
Sensitivity and Specificity
Serologic Tests / methods*
Trypanosoma cruzi / isolation & purification*

Substances

Neuraminidase