Abstract
Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of terpenylquinones/hydroquinones. Several compounds have shown IC50 values under the microM level.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Death / drug effects
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Humans
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Hydroquinones / chemical synthesis*
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Hydroquinones / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Quinones / chemical synthesis*
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Quinones / pharmacology
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Structure-Activity Relationship
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Terpenes / chemical synthesis*
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Terpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Hydroquinones
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Quinones
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Terpenes