Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy

A P Mizisin; G D Shelton; S Wagner; C Rusbridge; H C Powell

doi:10.1007/s004010050783

Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy

Acta Neuropathol. 1998 Feb;95(2):171-4. doi: 10.1007/s004010050783.

Authors

A P Mizisin¹, G D Shelton, S Wagner, C Rusbridge, H C Powell

Affiliation

¹ Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093-0612, USA. amizisin@ucsd.edu

PMID: 9498053
DOI: 10.1007/s004010050783

Abstract

Nerve biopsy samples from two cats with spontaneously occurring diabetes were examined. The predominant nerve fiber abnormalities observed were restricted to the myelin sheath and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were evident but the most striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy.

Publication types

Case Reports

MeSH terms

Animals
Cat Diseases*
Cats
Cell Division
Demyelinating Diseases / etiology
Demyelinating Diseases / pathology
Demyelinating Diseases / veterinary*
Diabetes Mellitus, Type 1 / pathology
Diabetes Mellitus, Type 1 / veterinary*
Diabetic Neuropathies / complications
Diabetic Neuropathies / pathology
Diabetic Neuropathies / veterinary*
Female
Male
Myelin Sheath / pathology*
Myelin Sheath / ultrastructure
Nerve Fibers / pathology
Nerve Fibers / ultrastructure
Neural Conduction
Orchiectomy
Ovariectomy
Schwann Cells / pathology*
Schwann Cells / ultrastructure