[Is the profile of antihypertensive drug utilization justified?]

Aten Primaria. 1997 Dec;20(10):530-4.
[Article in Spanish]

Abstract

Objective: To describe the use of drugs to combat hypertension and to assess prescription in function of their counterindications to diuretics and beta blockers.

Design: A descriptive cross-sectional study by means of an outside audit of clinical records.

Setting: 11 urban Health Districts opened before 1991.

Participants: 326 histories of adult hyperintense patients under pharmacological treatment were chosen at random (June-December, 1994).

Measurements and main results: Data were gathered on age, sex, present and former medication, reason for change, and counter-indications to diuretic or beta blocker treatments. Average age was 64.7 (SD 11.6); 66% were women. 437 active principles (AP) were used, of which Enalapril (68 patients) and Captopril (67) were the most common. 203 patients (62.3%; Cl 95%, 57.0-67.5) took one AP; 90 (27.6%; Cl 95%, 22.8-32.5) took two APs; 30 (9.2%), three APs; and 3 (0.9%), four APs. 47.8% of monotherapy was performed with ACE inhibitors; 27.6% with calcium antagonists; 15.3% with diuretics; 7.9% with beta blockers and 1.5% with alpha inhibitors. Diuretics were the drugs most commonly used in association.

Conclusions: There is little use of diuretics and beta blockers, but two-thirds of the prescription of other treatments are justified by a counter-indication to first-choice drugs.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adrenergic alpha-Antagonists / therapeutic use
  • Adrenergic beta-Antagonists / therapeutic use
  • Adult
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Antihypertensive Agents / therapeutic use*
  • Calcium Channel Blockers / therapeutic use
  • Captopril / therapeutic use
  • Contraindications
  • Cross-Sectional Studies
  • Diuretics / therapeutic use
  • Drug Prescriptions
  • Drug Utilization
  • Enalapril / therapeutic use
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Middle Aged
  • Spain
  • Urban Population

Substances

  • Adrenergic alpha-Antagonists
  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Diuretics
  • Enalapril
  • Captopril