Abstract
Ketamine and medetomidine produced chemical restraint for minor procedures in mice. Male mice required 50 mg/kg ketamine, 10 mg/kg medetomidine intraperitoneally (i.p.), and females a higher dose of ketamine (75 mg/kg i.p.). The onset of restraint effects, judged by loss of righting reflex, was more rapid in males than females. The effects were reversed using atipamezole (1-2.5 mg/kg). Recovery following administration of atipamezole was more rapid in males than females. We conclude that ketamine/medetomidine, followed by reversal with atipamezole, is an effective technique for chemical restraint in the mouse.
MeSH terms
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Adrenergic alpha-Agonists / administration & dosage
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Adrenergic alpha-Antagonists / administration & dosage
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Adrenergic alpha-Antagonists / pharmacology
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Analgesics, Non-Narcotic / administration & dosage
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Analgesics, Non-Narcotic / antagonists & inhibitors
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Anesthesia / methods
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Anesthesia / veterinary*
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Anesthesia Recovery Period
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Anesthetics, Combined* / administration & dosage
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Anesthetics, Combined* / antagonists & inhibitors
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Animals
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Body Temperature
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Female
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Hypnotics and Sedatives / administration & dosage
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Hypnotics and Sedatives / antagonists & inhibitors
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Imidazoles / administration & dosage
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Imidazoles / antagonists & inhibitors
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Imidazoles / pharmacology
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Immobilization*
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Ketamine / administration & dosage
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Ketamine / antagonists & inhibitors
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Male
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Medetomidine
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Mice / physiology*
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Oximetry
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Pilot Projects
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Random Allocation
Substances
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Adrenergic alpha-Agonists
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Adrenergic alpha-Antagonists
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Analgesics, Non-Narcotic
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Anesthetics, Combined
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Hypnotics and Sedatives
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Imidazoles
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atipamezole
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Ketamine
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Medetomidine