Purification and characterization of anti-Listeria compounds produced by Geotrichum candidum

Appl Environ Microbiol. 1998 Feb;64(2):800-3. doi: 10.1128/AEM.64.2.800-803.1998.

Abstract

Geotrichum candidum can produce and excrete compounds that inhibit Listeria monocytogenes. These were purified by ultrafiltration, centrifugal partition chromatography, thin-layer chromatography, gel filtration, and high-pressure liquid chromatography, and analyzed by liquid chromatography-mass spectrometry, infrared spectrometry, nuclear magnetic resonance spectrometry, and optical rotation. Two inhibitors were identified: D-3-phenyllactic acid and D-3-indollactic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Lactates / isolation & purification*
  • Lactates / pharmacology*
  • Listeria / drug effects*
  • Mitosporic Fungi / metabolism*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Lactates
  • 3-phenyllactic acid