Abstract
Three new bistetrahydrofuran acetogenins, carolins A-C (1-3), were isolated from the MeOH extract of Annona spinescens in addition to the known compound, squamocin (4). The structures of 1, 2, and 3 were elucidated by spectroscopic methods including LSIMS/MS technique and confirmed by a chemical transformation, The cytotoxic activity of the new compounds 1-3 is reported and discussed in comparison with 4 and the previously isolated spinencin (5).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chlorocebus aethiops
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Drug Screening Assays, Antitumor
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Fatty Alcohols / isolation & purification*
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Fatty Alcohols / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plants, Medicinal / chemistry*
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Seeds / chemistry
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
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Vero Cells
Substances
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Antineoplastic Agents, Phytogenic
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Fatty Alcohols
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carolin A
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carolin B
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carolin C
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4-Butyrolactone