Three new bistetrahydrofuran acetogenins from the seeds of Annona spinescens

J Nat Prod. 1998 Jan;61(1):34-9. doi: 10.1021/np9703252.

Abstract

Three new bistetrahydrofuran acetogenins, carolins A-C (1-3), were isolated from the MeOH extract of Annona spinescens in addition to the known compound, squamocin (4). The structures of 1, 2, and 3 were elucidated by spectroscopic methods including LSIMS/MS technique and confirmed by a chemical transformation, The cytotoxic activity of the new compounds 1-3 is reported and discussed in comparison with 4 and the previously isolated spinencin (5).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / isolation & purification
  • 4-Butyrolactone / pharmacology
  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chlorocebus aethiops
  • Drug Screening Assays, Antitumor
  • Fatty Alcohols / isolation & purification*
  • Fatty Alcohols / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plants, Medicinal / chemistry*
  • Seeds / chemistry
  • Spectrophotometry, Ultraviolet
  • Tumor Cells, Cultured
  • Vero Cells

Substances

  • Antineoplastic Agents, Phytogenic
  • Fatty Alcohols
  • carolin A
  • carolin B
  • carolin C
  • 4-Butyrolactone