Abstract
The clinical, pathological and radiological manifestations of type 1 Gaucher disease and the role of imaging techniques such as CT, MRI and sulfur-colloid scintigraphy in the management of these patients is discussed. MRI appears to be the most valuable imaging technique for evaluating bone marrow involvement and detecting disease activity. MRI is also useful in assessing therapeutic responses to enzyme replacement therapy.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adolescent
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Adult
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Bone Diseases / diagnosis*
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Bone Diseases / therapy
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Bone Marrow / diagnostic imaging
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Bone Marrow / pathology
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Bone and Bones / diagnostic imaging
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Bone and Bones / pathology
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Child
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Female
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Gaucher Disease / diagnosis*
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Gaucher Disease / therapy
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Glucosylceramidase / therapeutic use*
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Humans
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Magnetic Resonance Imaging
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Male
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Radionuclide Imaging
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Recombinant Proteins / therapeutic use
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Splenectomy
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Tomography, X-Ray Computed
Substances
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Recombinant Proteins
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alglucerase
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Glucosylceramidase
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imiglucerase